The problem with a lot of modern horror-thriller sci-fi films is that it’s quite obvious which characters will survive and which ones won’t. I think, over the decades, plot twists that seemed original are much more commonplace now, but Annihilation avoids most of that by telling the audience the result of the expedition in its very first scenes. Self-destruction is briefly mentioned in a line of dialogue but it’s a pervasive theme throughout the entire film, and one of its strengths is showing how each character deals with death and pain and how they ultimately choose to end their fight.